Hydroxyamine hydrochloride → HCID 86748111, compound

Participants

Reaction Steps

A solution of hydroxylamine hydrochloride (0.089 g) in 1N sodium hydroxide solution (1.3 mL) was added to a solution of 4-[2-(2-naphthalenyloxy)ethoxy]-alpha-oxobenzeneacetic acid (0.291 g) in dimethylformamide and the mixture was heated on a steam bath till all the solids dissolved. The reactants were maintained in solution by intermittent heating over 2 hours, then the mixture was stirred at room temperature overnight. The formed precipitate was filtered off, then the filtrate was diluted with water and adjusted to pH 2 by the addition of dilute hydrochloric acid solution. The resulting solid was recovered by filtration and dried in vacuo to furnish 0.164 g of (Z)-alpha-(hydroxyimino-4-[2-(2-naphthalenyloxy)ethoxy]benzeneacetic acid, mp 178°-179° C.

Provenance & Evidence