Pyridine → HCID 86748119, compound

Participants

Reaction Steps

As described in example 305, 5-[2-(2-naphthalenyloxy)ethoxy]-alpha-oxo-2-thiopheneacetic acid (0.34 g) was combined with ethoxylamine hydrochloride (0.130 g) in pyridine (5 mL) and stirred for 10 days at room temperature. The rnixmre of isomers, obtained after work up of the reaction in the usual manner, were separated by flash chromatography over silica gel (70 g: dichlorornethane-hexane; 4:1 ). Fractions containing the less polar isomer were evaporated to give 0.151 g of (Z)-alpha-(ethoxyimino)-5-[2-(2-naphthalenyloxy)ethoxy]-2-thiopheneacetic acid ethyl ester, mp 114°-115.5° C.

Provenance & Evidence