2-Methyl-3-nitrobenzoic acid → 3-Amino-2-methylbenzoic acid

Participants

Reaction Steps

A solution of 2-methyl-3-nitrobenzoic acid (top. 182-184° C., 22 g, 0.12 mol) in 400 mL of methanol was hydrogenated over platinum oxide (100 rag) for 45 minutes at 55 psi, whereupon the catalyst was filtered off through a bed of Celite® (50 g), and the solvent evaporated under reduced pressure to give 3-amino-2-methylbenzoic acid (top. 178-181° C.) in quantitative yield (18.3 g).

Provenance & Evidence