Dimethyl Sulfoxide → Dibenzoylmethane

Participants

Reaction Conditions

Reaction Steps

100 g of anhydrous dimethyl sulfoxide, 100 g of diethylene glycol dimethyl ether, 6 g of absolute methanol and 18 g of sodium methylate (97%) are charged to an apparatus as described in Example 1. A mixture of 45 g of methyl benzoate and 36 g of acetophenone are added dropwise to this mixture at 25 ° C. over 45 minutes. After this addition, the reaction mixture is stirred for 2 hours at 30° C. and the solvent is removed by vacuum distillation at a temperature of <60 ° C. The residue is diluted with 150 g of methyl tert-butyl ether, cooled to 0° C. and filtered. The filter cake is washed twice with methyl tert-butyl ether. The pale grey solid is thereafter taken up in dilute hydrochloric acid and stirred.

Provenance & Evidence