HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetophenone → 8-Hydroxy-1-phenyl-1,3-octanedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetophenone | HCID 7410 | — |
| Reactant | epsilon-CAPROLACTONE | HCID 10401 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 8-Hydroxy-1-phenyl-1,3-octanedione | HCID 18964051 | — |
Reaction Steps
In accordance with the procedure of Example 8, 61.3 g of acetophenone and 57.7 g of ε-caprolactone are condensed in 117.0 g of N-methylpyrrolidone as solvent with 52.9 g of sodium tert-butylate (97%) as base. Working up is as described in Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05344992 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-42a455ad1fce4f2f8331c9e7ac13cb58 |
| Source note | uspto-grants-1994_09 |