反应详情

Following the synthetic procedure outlined in Step 3 of Example 1, 280 mg (0.93 mmol) of 1-(2-bromocyclopenten-1-yl)-4-(methylthio)benzene (Example 1, Step 2) was reacted with 350 mg (1.9 mmol) of 2,4-dichlorophenylboronic acid (Lancaster). Purification by silica gel chromatography (MPLC) with hexane gave 280 mg of 1-[2-(2,4-dichlorophenyl)cyclopenten-1-yl]-4-(methylthio)benzene as an oil: NMR (CDCl3) d 2.10 (m, J=7 Hz, 2H) , 2.41 (s, 3H) , 2.81 (t, J=8 Hz, 4H) , 2.92 (m, J=8 Hz, 2H) , 6.95-7.21 (m, 6H) , 7.40 (s, 1H) .

1. customPurification by silica gel chromatography (MPLC) with hexane