HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → (S)-1-(N-(3,5-Dichlorophenyl)-N-phenylcarbamoyl)-2-(2-(N-methyl-N-(2-methoxybenzyl)amino)ethylaminocarbonyl)-4-(N,N-di-n-pentylcarbamoyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N1-(2-methoxybenzyl)-N1-methylethane-1,2-diamine | HCID 6484249 | — |
| Reactant | (S)-1-[N-(3,5-Dichlorophenyl)-N-phenylcarbamoyl]-4-(N,N-di-n-pentylcarbamoyl)piperazine-2-carboxylic acid | HCID 54538500 | — |
| Product | (S)-1-(N-(3,5-Dichlorophenyl)-N-phenylcarbamoyl)-2-(2-(N-methyl-N-(2-methoxybenzyl)amino)ethylaminocarbonyl)-4-(N,N-di-n-pentylcarbamoyl)piperazine | HCID 54559192 | 90% |
Reaction Steps
According to the procedure of Example 1, Step E above, 46 mg (0.080 mmole) of (S)-1-[N-(3,5-dichlorophenyl)-N-phenylcarbamoyl]-4-(N,N-di-n-pentylcarbamoyl)piperazine-2-carboxylic acid, 12 mg (0.088 mole) of HOBt, 21 mg (0.112 mmole) of EDAC, and 31 mg (0.16 mmole) of N-(2-methoxybenzyl)-N-methylethylenediamine (from Example 1, Step E b) above) after purification by flash chromatography on 16 g of silica gel eluting with 100:5:CH2Cl2 :methanol: provided 54 mg (90%) of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05344830 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-2da00f8d6a1a4f28b9f8ba0f24b8a638 |
| Source note | uspto-grants-1994_09 |