HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 18654568, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 22850669 | HCID 22850669 | — |
| Reactant | HCID 70083324 | HCID 70083324 | — |
| Product | HCID 18654568 | HCID 18654568 | 70% |
Reaction Steps
According to the procedure of Example 1, Step E above, 60 mg (0.12 mmole) of (S)-4-(dipentylcarbamoyl)-1-(N,N-diphenylcarbamoyl)piperazine-2carboxylic acid, 18 mg (0.13 mmole) of HOBt, 32 mg (0.17 mmole) of EDAC, 86 mg (ca. 0.24 mmole) of N-(benzyloxycarbonyl)-N-(carbamoylmethyl)ethylenediamine trifluoroacetic acid salt and 33 microliters (0.24 mmole) of triethylamine after purification by flash chromatography on 16 g of silica gel eluting with 450 mL of 100:3.5 CH2Cl2 :methanol followed by flash chromatography on 16 g of silica with 450 mL of 100:3 CH2Cl2 :methanol then 200 mL of 100:5 CH2Cl2 :methanol gave 62 mg (70%) of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05344830 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-417ebd422c1049a8ae750be062823a56 |
| Source note | uspto-grants-1994_09 |