反应详情

A solution of 1.80 g (14.50 mmol) of 2-(2-hydroxyethyl)pyrazine in 40 ml of methanol was hydrogenated over 24 hours using 0.8 g of platinum oxide, The reaction was filtered through Celite and TLC (10% methanol/0.2% ammonium hydroxide/chloroform) revealed that the reaction was 50% complete. The material was redissolved in 50 ml of methanol and hydrogenated again under the same conditions. The mixture was filtered through Celite and rinsed with 45 ml of methanol. Concentration in vacuo yielded 1.86 g (98%) of a yellow oil.

1. filtrationThe reaction was filtered through Celite and TLC (10% methanol/0.2% ammonium hydroxide/chloroform)
2. dissolutionThe material was redissolved in 50 ml of methanol
3. filtrationThe mixture was filtered through Celite
4. washrinsed with 45 ml of methanol
5. concentrationConcentration in vacuo