Triphenylphosphine dibromide → HCID 19004128, compound

Participants

Reaction Steps

A solution of 312 mg (0.61 mmol) of (RS)-1-(N,N-diphenylcarbamoyl)-2-(2-hydroxyethyl)-4-(N,N-dipentylcarbamoyl)piperazine and 362 mL (0.86 mmol) of dibromotriphenylphosphorane in 15 mL of acetonitrile was stirred under nitrogen at 82° C. for 2 hours. The yellow solution was cooled and concentrated in vacuo. Flash chromatography on 35 g of silica gel using 1:1 v/v ethyl acetate/hexane as the eluant afforded 300 mg (85%) of a yellow oil.

Provenance & Evidence