Methanol → HCID 18966212, compound

Participants

Reaction Steps

To a methanol solution of 2-(4,6-dimethoxy-2-pyrimidinylthio)-methyl butyraldehyde (1.5 g) was added sodium boron hydride (0.2 g), followed by a five-minute stirring at room temperature. Water was then added to the reaction liquid, followed by extraction with ethyl acetate, water-washing of the resulting organic layer and drying thereof in that order. After the removal of the drying agent from the reaction product under filtration, followed by separation of ethyl acetate under reduced pressure distillation, there was obtained an oily substance that was then purified by silica gel column chromatography to obtain the desired 2-(4,6-dimethoxy-2-pyrimidinylthio)-3-methylbutanol (1.3 g) n20D 1.5445.

Provenance & Evidence