HCID 15070585, compound → HCID 15765402, compound

Participants

Reaction Steps

A tetrahydrofuran solution of methyl 2-(4,6-dimethoxy-2-Pyrimidinylthio)-hexanoate (3.2 g) was added dropwise to a tetrahydrofuran suspension of aluminum lithium hydride (0.7 g) under ice-cooling, followed by 30 minutes stirring at room temperature, addition thereto of water and removal therefrom of precipitates by filtration. Then tetrahydrofuran was distilled off form the reaction liquid under reduced pressure and the resulting residue was subjected to silica gel column chromatography, to obtain the desired 2-(4,6-dimethoxy-2-pyrimidinylthio)hexanol (2.7 g). nD 1.5303.

Provenance & Evidence