Sodium Trifluoroacetate → HCID 53759503, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6.0 g (0.044 mole) of sodium trifluoroacetate, 4.18 g (0.022 mole) of copper(I)iodide, and 40 mL of N,N-dimethylacetamide under a nitrogen atmosphere at 140 ° C is added 4.83 g (0.011 mole) of 3-(7-bromo-2,2-dimethyl-5-fluoro- 1,3-benzodioxol-4-yl)- 1 -methyl-6-trifluoromethyluracil (Example 3). The temperature is then raised to 150° C. at which the reaction mixture is stirred for three hours. After being cooled to ambient temperature, the reaction mixture is poured into ice and then extracted with diethyl ether. The combined extracts are dried over anhydrous magnesium sulfate and filtered. The filtrate is evaporated under reduced pressure, leaving a residue which is purified using column chromatography on silica gel. The product-containing fractions are combined and the solvent evaporated under reduced pressure, leaving 3-(2,2-dimethyl-5-fluoro-7-trifluoromethyl- 1,3-benzodioxol-4-yi)- 1 -methyl-6-trifluoromethyluracil as a residue.

Provenance & Evidence