Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 15230395, compound

Participants

Reaction Steps

By the procedure described in Example 6, hydrogenation of 3-(4-pyridinyl)-1-azabicyclo[2.2.2]oct-2-ene dihydrochloride (1.07 g, prepared as in Example 10c) gave 0.75 g of the title compound as the dihydrochloride salt; m.p. 210°-220° C.; Found: C, 54.18; H, 6.93; N, 10.54. C12H18N2Cl2.0.25H2O requires C, 54.25; H, 7.02; N, 10.54; δ(360 MHz, D2O) 8.772 (2H, d, J=6.8 Hz, py-H), 8.063 (2H, m, J=6.8 Hz, py-H), 4.00-3.30 (6H, m, H2 -2, H2 -6 and H2 -7) 2.60-1.85 (5H, m, H-4, H2 -5 and H2 -8); m/e 188 (M+).

Provenance & Evidence