3-[N-(3-Phthalimidopropyl)amino]-5-methoxychroman → 3-[N-Propyl-N-(3-phthalimidopropyl)amino]-5-methoxychroman

HRID 2226181Notes

Reaction equation

HRID 2226181 reaction equation
[C:1]1(=O)N(CCCCNC2CC3C(=CC=CC=3OC)OC2)C(=O)C2=CC=C[CH:27]=[C:2]12.[C:29]1(=[O:55])[N:33]([CH2:34][CH2:35][CH2:36][NH:37][CH:38]2[CH2:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][C:45]=3[O:48][CH3:49])[O:40][CH2:39]2)[C:32](=[O:50])[C:31]2=[CH:51][CH:52]=[CH:53][CH:54]=[C:30]12>>[CH2:1]([N:37]([CH:38]1[CH2:47][C:46]2[C:41](=[CH:42][CH:43]=[CH:44][C:45]=2[O:48][CH3:49])[O:40][CH2:39]1)[CH2:36][CH2:35][CH2:34][N:33]1[C:32](=[O:50])[C:31]2=[CH:51][CH:52]=[CH:53][CH:54]=[C:30]2[C:29]1=[O:55])[CH2:2][CH3:27]

Participants

3

Reactant 2

HCID 102483303-[N-(3-Phthalimidopropyl)amino]-5-methoxychromanHCID 104298593-[N-(4-Phthalimidobutyl)amino]-5-methoxychroman

Product 1

HCID 100700293-[N-Propyl-N-(3-phthalimidopropyl)amino]-5-methoxychromanYield 76%

Procedure

Using the procedure described in Example 2, but replacing the compound of Example 1 by the compound of Example 3, the expected product is obtained.

Sources & evidence

ORD record
ord-d5a91ed45b9b46ad9619214bc32526b3
Source dataset
uspto-grants-1994_09
Patent number
US05346916

Reaction notes

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