Oxalic Acid → (+)-3-[4-[N-n-Propyl-N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane (Oxalate)

HRID 2226188Notes

Reaction equation

HRID 2226188 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH:6]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[C:22](=[O:23])[C:21]3([CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:20][C:19]1=[O:29])[CH2:7][O:8]2.[C:30]([OH:35])(=[O:34])[C:31]([OH:33])=[O:32].CO[C:38]1[CH:47]=CC=C2[C:39]=1CC(NCCCCN1C(=O)C3(CCCCC3)CC1=O)CO2.C(O)(=O)C(O)=O>>[C:30]([OH:35])(=[O:34])[C:31]([OH:33])=[O:32].[CH2:39]([N:13]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[C:22](=[O:23])[C:21]2([CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[CH2:20][C:19]1=[O:29])[CH:6]1[CH2:5][C:4]2[C:9](=[CH:10][CH:11]=[CH:12][C:3]=2[O:2][CH3:1])[O:8][CH2:7]1)[CH2:38][CH3:47]

Participants

4

Reactant 3

HCID 971Oxalic AcidHCID 18966575(+)-3-[4-[N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]DecaneHCID 18966585(+)-3-{4-[N-(5-Methoxy-3-Chromanyl)Amino]Butyl}-2,4-Dioxo-3-Azaspiro[4.5]Decane Oxalate

Product 1

HCID 18966570(+)-3-[4-[N-n-Propyl-N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane (Oxalate)

Procedure

Using the procedure described in Example 10, but replacing the compound of Example 9 by the compound of Example 28, the product of the title is obtained. It is salified with oxalic acid.

Workup

  1. customthe product of the title is obtained

Sources & evidence

ORD record
ord-99008ff41d974c53810c472edd229380
Source dataset
uspto-grants-1994_09
Patent number
US05346916

Reaction notes

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