(+)-3-[4-[N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane → (+)-3-[4-[N-n-Propyl-N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane (Oxalate)

HRID 2226189Notes

Reaction equation

HRID 2226189 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH3:7][O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH:12]([NH:19][CH2:20][CH2:21][CH2:22][CH2:23][N:24]1[C:28](=[O:29])[C:27]3([CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)[CH2:26][C:25]1=[O:35])[CH2:13][O:14]2.CO[C:38]1[CH:47]=CC=C2[C:39]=1CC(NCCCCN1C(=O)C3(CCCCC3)CC1=O)CO2>>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH2:39]([N:19]([CH2:20][CH2:21][CH2:22][CH2:23][N:24]1[C:28](=[O:29])[C:27]2([CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[CH2:26][C:25]1=[O:35])[CH:12]1[CH2:11][C:10]2[C:15](=[CH:16][CH:17]=[CH:18][C:9]=2[O:8][CH3:7])[O:14][CH2:13]1)[CH2:38][CH3:47]

Participants

3

Reactant 2

HCID 18966575(+)-3-[4-[N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]DecaneHCID 18966585(+)-3-{4-[N-(5-Methoxy-3-Chromanyl)Amino]Butyl}-2,4-Dioxo-3-Azaspiro[4.5]Decane Oxalate

Product 1

HCID 18966570(+)-3-[4-[N-n-Propyl-N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane (Oxalate)

Procedure

Using the procedure described in Example 29, but replacing the compound of Example 28 by the compound of Example 30, the product of the title is obtained.

Workup

  1. customthe product of the title is obtained

Sources & evidence

ORD record
ord-49b87e04ab7340c8964939a420b85ca1
Source dataset
uspto-grants-1994_09
Patent number
US05346916

Reaction notes

Loading…