HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 5-(t-Butyldimethylsiloxy)-3-pentyne
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 3-Butyn-1-OL | HCID 13566 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(t-Butyldimethylsiloxy)-3-pentyne | HCID 11019857 | — |
Reaction Steps
To a solution of 3-butyn-1-ol (g) (10.0 g) in DMF (80 ml) were added t-butyldimethylsilyl chloride (21.5 g) and imidazol (10.6 g), and the resultant mixture was kept at 35° C. for 7 hours. The reaction mixture was treated in the conventional manner and the obtained crude product was distilled to give the title compound (h).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05346921 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-3d1d009b1224421191ca81f27304fe26 |
| Source note | uspto-grants-1994_09 |