Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2226249Generated: October 27, 2026

Azacyclonol → 4'-tert-Butyl-4-(4-(hydroxybenzhydryl)piperidino)butyrophenone

https://huagongshe.com/reaction/2226249

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAzacyclonolHCID 15723—
Reactant4'-tert-Butyl-4-chlorobutyrophenoneHCID 2723694—
Product4'-tert-Butyl-4-(4-(hydroxybenzhydryl)piperidino)butyrophenoneHCID 39380—

Reaction Steps

reacting azacyclonol with 4 -chloro-1-[4-(1,1-dimethylethyl)phenyl]-1-butanone to yield terfenadone free-base;

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05347006
Source datasetuspto-grants-1994_09
ORD IDord-d247b3c16c41478aa93105ae3f464e35
Source noteuspto-grants-1994_09