HCID 58100962, compound → HCID 66810434, compound

HRID 222628Notes

Reaction equation

COC(C1N=C2N([CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]3)C3C=CC=CC=3N2C(=O)C=1OC(=O)C)=O.C(OC(N1CCN(CC[N:53]2[C:57]3=[N:58][C:59]([C:64](=[O:75])[NH:65][CH2:66][C:67]4[CH:72]=[CH:71][C:70]([Cl:73])=[C:69]([Cl:74])[CH:68]=4)=[C:60]([OH:63])[C:61](=[O:62])[N:56]3[C:55]3[CH:76]=[CH:77][CH:78]=[CH:79][C:54]2=3)CC1)=O)(C)(C)C>>[C:30]([O:29][C:27]([N:24]1[CH2:25][CH2:26][N:21]([CH2:20][CH2:19][N:58]2[C:59]([C:64](=[O:75])[NH:65][CH2:66][C:67]3[CH:72]=[CH:71][C:70]([Cl:73])=[C:69]([Cl:74])[CH:68]=3)=[C:60]([OH:63])[C:61](=[O:62])[N:56]3[C:55]4[CH:76]=[CH:77][CH:78]=[CH:79][C:54]=4[N:53]=[C:57]23)[CH2:22][CH2:23]1)=[O:28])([CH3:33])([CH3:32])[CH3:31]

Participants

Reactant 2

HCID 58100962HCID 58100962, compound

HCID 58101071HCID 58101071, compound

Product 1

HCID 66810434HCID 66810434, compound

Procedure

The product from Example 15.2 was converted to 4-{2-[2-(3,4-Dichloro-benzylcarbamoyl)-3-hydroxy-4-oxo-4H-benzo[4,5]imidazo[1,2-a]pyrimidin-10-yl]-ethyl}-piperazine-1-carboxylic acid tert-butyl ester following a procedure adapted from Example 6.

Sources & evidence

ORD record: ord-016f46e3e7df479bb99f2b99d31d3fdf
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08207334B2

Reaction notes

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