HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2-(3-Chlorophenyl)-2-hydroxyacetic acid → N-[(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl]-(S)-3-chloromandelamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2-(3-Chlorophenyl)-2-hydroxyacetic acid | HCID 2733127 | — |
| Reactant | (S)-2-(3-Chlorophenyl)-2-hydroxyacetic acid | HCID 5324675 | — |
| Reactant | (S)-7-Amino-5,6,7,8-tetrahydro-naphthalen-2-OL hydrochloride | HCID 67824357 | — |
| Product | N-[(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl]-(S)-3-chloromandelamide | HCID 9973978 | — |
| Product | (R)-7-Amino-5,6,7,8-tetrahydro-naphthalen-2-ol hydrochloride | HCID 67824356 | — |
Reaction Steps
By following the procedure described in PREPARATION IX and substituting the (S)-3-chloromandelic acid for the (R)-3-chloromandelic acid and the (S)-2-amino-7-hydroxytetralin hydrochloride, PREPARATION IV, for the (R)-2-amino-7-hydroxytetralin hydrochloride, the N-[(2S)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl]-(S)-3-chloromandelamide, SR 58574, is obtained; m.p. 145°-146° C.; /alpha/=-34.2° (methanol, c=1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05347037 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-7cb7fbc20ea9462bbf6db959968ae017 |
| Source note | uspto-grants-1994_09 |