Tetramethyl pyrazine-2,3,5,6-tetracarboxylate → 2,3,5,6-Tetramethoxycarbonylpiperazine

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Reaction Steps

A solution of tetrakis-methoxycarbonylpyrazine (5.3g, 16.9 mmol) (prepared in accordance with J. Org. Chem. 37 (19) , p2963 (1972)) in 800 ml of dry ethanol, was hydrogenated at 50 bar in the presence of 10 g 5% palladium on charcoal at 80 ° C. for 16 hours. After cooling, the solution was filtered and evaporated to give slightly yellow crystals. Yield: 4.8 g (90%) , mp. 162°-163° C. (Lit. 162°-163° C.). NMR confirmed the structure.

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