HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Ethanedithiol → 7-benzyloxycarbonyl-1,4-dithia-7-azaspiro [4.4]nonane-8(S)carboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Ethanedithiol | HCID 10902 | — |
| Reactant | Ethyl (S)-1-Cbz-4-oxopyrrolidine-2-carboxylate | HCID 14540986 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-benzyloxycarbonyl-1,4-dithia-7-azaspiro [4.4]nonane-8(S)carboxylic acid, ethyl ester | HCID 14540988 | — |
Reaction Steps
As described in Example 23, react 1-benzyloxycarbonyl-4-keto-(S)-proline, ethyl ester (prepared from the acid by esterification in ethanol) with 1,2-ethanedithiol to obtain 7-benzyloxycarbonyl-1,4-dithia-7-azaspiro [4.4]nonane-8(S)carboxylic acid, ethyl ester, a yellow oil [α]D26 -21.0° (ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05348944 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-ab38eb5af0614fbfb34d4b88e74bb901 |
| Source note | uspto-grants-1994_09 |