Sodium Hydroxide → HCID 22827555, compound

HRID 2226409Notes

Reaction equation

[C:1]([CH:6]([NH:15][CH2:16][C:17]([N:19]1[C@H:27]([C:28]([OH:30])=[O:29])[CH2:26][C:21]2([S:25][CH2:24][CH2:23][S:22]2)[CH2:20]1)=[O:18])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([O:3]CC)=[O:2].[OH-].[Na+]>>[C:1]([CH:6]([NH:15][CH2:16][C:17]([N:19]1[C@H:27]([C:28]([OH:30])=[O:29])[CH2:26][C:21]2([S:25][CH2:24][CH2:23][S:22]2)[CH2:20]1)=[O:18])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([OH:3])=[O:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 13373622HCID 13373622, compound

Product 1

HCID 22827555HCID 22827555, compound

Procedure

As described in Example 24, hydrolyze 7-[N-(1-carboethoxy-3-phenylpropyl )glycyl]-1,4-dithia-7-azaspiro[4.4 ]nonane-8(S)-carboxylic acid (prepared as described in Example 31) with sodium hydroxide to give the title compound.

Sources & evidence

ORD record: ord-f9465fefc94a48c3a0c4a6549fc52017
Source dataset: uspto-grants-1994_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05348944

Reaction notes

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