Sodium Hydroxide → HCID 67852548, compound

Participants

Reaction Steps

To a solution of 1-[N-(1-ethoxycarbonyl-3-phenylpropyl) (S)-alanyl]azacyclooctane-2(S)-carboxylic acid (prepared as described in Example 41) in ethanol, add 0.25N sodium hydroxide. After three hours, concentrate the reaction mixture and absorb it on an XAD-2 resin column and elute with water and then with methanol. Concentrate the methanol eluant to give a residue and absorb this residue on a silica gel column and elute with chloroform:methanol: 14% ammonium hydroxide 1:1:1. Concentrate the desired eluant fractions to obtain the title compound.

Provenance & Evidence