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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2226424Generated: October 30, 2026

Sodium cyanoborohydride → 1-[N-(1-Carboethoxy-3-p-chlorophenylpropyl)-(S)-alanyl]-hexahydrofuro[3,4-b]pyrrole-2(S)-carboxylic acid

https://huagongshe.com/reaction/2226424

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium cyanoborohydrideHCID 5003444—
ReactantEthyl 4-(4-chlorophenyl)-2-oxobutanoateHCID 13201328—
Reactant1-[(S)-alanyl]hexahydrofuro[3,4-b]pyrrole-2(S)-carboxylic acidHCID 18654890—
SolventEthanolHCID 702—
Product1-[N-(1-Carboethoxy-3-p-chlorophenylpropyl)-(S)-alanyl]-hexahydrofuro[3,4-b]pyrrole-2(S)-carboxylic acidHCID 86748149—

Reaction Steps

Treat 1-[(S)-alanyl]hexahydrofuro[3,4-b]pyrrole-2-(S)-carboxylic acid (prepared as described in Example 47) and ethyl 4-(p-chlorophenyl)-2-oxobutyrate with sodium cyanoborohydride as described in Example 47D (ethanol solvent) to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05348944
Source datasetuspto-grants-1994_09
ORD IDord-32e21e4980354475b00ca99b94b9f7fc
Source noteuspto-grants-1994_09