Sodium Hydroxide → HCID 18655002, compound

HRID 2226425Notes

Reaction equation

[C:1]([CH:6]([NH:15][CH2:16][C:17]([N:19]1[C@H:27]([C:28]([OH:30])=[O:29])[CH2:26][C:21]2([CH2:25][S:24][CH2:23][CH2:22]2)[CH2:20]1)=[O:18])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([O:3]CC)=[O:2].[OH-].[Na+]>>[C:1]([CH:6]([NH:15][CH2:16][C:17]([N:19]1[C@H:27]([C:28]([OH:30])=[O:29])[CH2:26][C:21]2([CH2:25][S:24][CH2:23][CH2:22]2)[CH2:20]1)=[O:18])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([OH:3])=[O:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18654969HCID 18654969, compound

Product 1

HCID 18655002HCID 18655002, compound

Procedure

As described in Example 48, hydrolyse 7-[N-(1-carboethoxy-3-phenylpropyl)glycyl]-2-thia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid (prepared as described in Example 58 with sodium hydroxide to give the title compound.

Workup

customprepared

Sources & evidence

ORD record: ord-43ffd07dedeb4a66b08723d8cfe641ab
Source dataset: uspto-grants-1994_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05348944

Reaction notes

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