Hydrochloric Acid → HCID 85639286, compound

Participants

Reaction Conditions

Reaction Steps

Mix 3-chloropropyl isopentyl sulfide (1.0 g, 5.5 mmol) and piperidine (3.3 mL, 33 mmol) and heat at 125° C. for 2 hours. Cool to room temperature and partition between 50% sodium hydroxide and ethyl ether. Separate the organic phase, wash the aqueous phase with ethyl ether (2×30 mL), combine the organic phases and dry (MgSO4). Evaporate the solvent in vacuo to yield 1.12 g (89%). Dissolve the product (1.0 g) in ethyl ether (100 mL) and treat with anhydrous hydrochloric acid. Collect the resulting yellow solid by vacuum filtration, recrystallize (ethyl acetate) and dry to yield 0.723 g of the title compound as white crystals; mp 155°-8° C. 438E-83

Provenance & Evidence