Piperidine → HCID 18965292, compound

Participants

Reaction Steps

Heat 3-chloropropyl isopentyl sulfone (700 mg, 3.29 mmol) and piperidine (1.7 g, 20 mmol) at 125° C. for 45 minutes. Cool to room temperature, treat with 5N sodium hydroxide, extract with ethyl acetate (3×25 mL), and dry (MgSO4). Concentrate in vacuo to yield 850 mg orange oil. Purify by silica gel chromatography (50% ethyl acetate/methanol) to yield 500 mg of the title compound as a pale yellow oil.

Provenance & Evidence