HCID 10593901, compound → HCID 54127070, compound

Participants

Reaction Steps

A suspension of platinum oxide (0.35 g) in ethyl acetate (100 ml) containing methyl 4-chloro-2-(3-nitrophenyl)acetamidobenzoate (9.96 g, 28.6 mmol) was shaken under an atmosphere of hydrogen at 40 psi until hydrogen uptake had ceased. The suspension was filtered and the filtrate evaporated to leave methyl 2-(3-aminophenyl)acetamido-4-chlorobenzoate as a pale green solid (9.22 g); δ(CDCl3) 3.65 (2H, s, CH2), 3.66 (3H, s, OCH3), 6.61 (1H, dd, J 7.9 and 2.1 Hz, ArH), 6.70 (1H, s, ArH), 6.74 (1H, d, J 7.6 Hz, ArH), 7.01 (1H, dd, J 8.6 and 2.0 Hz, 5-H), 7.14 (1H, d, J 7.7 Hz, ArH), 7.89 (1H, d, J 8.6 Hz, 6-H), 8.81 (1H, d, J 2.0 Hz, 3-H) and 11.03 (1H, br s, CONH).

Provenance & Evidence