Acetic Anhydride → Acetamide, N-(3,5-dimethylphenyl)-

Participants

Reaction Steps

To a solution of 15.2 g (125 mmole) of 3,5dimethylaniline in 60 mL of toluene was added 15 g (146 mmole) of acetic anhydride, whereupon the internal temperature rose to 75° C. The mixture was allowed to cool to room temperature and the solvent was removed in vacuo. The residue was dissolved in 150 mL of hot ethyl acetate and the solution allowed to stand for 16 hours. The resulting mixture was cooled at 5° C. for 3 hours and the solid collected by filtration to give 18.43 g (90%) of off-white crystals.

Provenance & Evidence