Methanol → HCID 15218719, compound

Participants

Reaction Steps

A 100-ml stainless steel autoclave purged with nitrogen in advance was charged with 5 g (0.0261 mol) of 6-phenyl-2,5-hexanedione and 10 ml of methanol. A solution of 0.185 g (0.13 mmol) of RuI(p-cymene)((R)-T-BINAP)]I3 in 2 ml of methylene chloride was added thereto, thereby conducting reaction at a reaction temperature of 50° C. for 36 hours under a hydrogen pressure of 50 kg/cm2. After distilling off the solvent, the residue was purified by column chromatography on a silica gel using a developing solvent of hexane/ethyl acetate (5/1) to obtain 3.03 g of (-)-5-hydroxy-6-phenylhexane-2-one (yield: 60.2%).

Provenance & Evidence