HRID2226726

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID75314

L-Asparagine, N2-[(phenylmethoxy)carbonyl]-

C12H14N2O5

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

HCID21866389

未命名化合物

结构：C[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)OCc1ccccc1

HCID178462202

未命名化合物

PRODUCTS

生成物

结构：C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)OCc1ccccc1

HCID178462154

未命名化合物

PROCEDURE

实验过程

The desired compound was prepared from 2.9 g of Boc-Ala-Pro-Arg(NO2)-OBzl, 15 ml of 4 N HCl-AcOEt, 1.4 g of Z-Asn-OH, 1.0 g of HOBt and 1.1 g of DCC in the same manner as in Example 7- (3 ) .

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9f4ed36036d449d4b71a6e00b9086421
来源数据集: uspto-grants-1994_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05349050
来源说明: uspto-grants-1994_09

反应 SMILES

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:4]([N:6]1[CH2:34][CH2:33][CH2:32][C@H:7]1[C:8]([NH:10][C@H:11]([C:22]([O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[CH2:12][CH2:13][CH2:14][NH:15][C:16](=[NH:21])[NH:17][N+:18]([O-:20])=[O:19])=[O:9])=[O:5])[CH3:3].Cl.CCOC(C)=O.[NH:49]([C:58]([O:60][CH2:61][C:62]1[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=1)=[O:59])[C@H:50]([C:55]([OH:57])=O)[CH2:51][C:52](=[O:54])[NH2:53].C1C=CC2N(O)N=NC=2C=1.C1CCC(N=C=NC2CCCCC2)CC1>>[NH:49]([C:58]([O:60][CH2:61][C:62]1[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=1)=[O:59])[C@H:50]([C:55]([NH:1][C@H:2]([C:4]([N:6]1[CH2:34][CH2:33][CH2:32][C@H:7]1[C:8]([NH:10][C@H:11]([C:22]([O:24][CH2:25][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)=[O:23])[CH2:12][CH2:13][CH2:14][NH:15][C:16](=[NH:21])[NH:17][N+:18]([O-:20])=[O:19])=[O:9])=[O:5])[CH3:3])=[O:57])[CH2:51][C:52](=[O:54])[NH2:53]