HRID2226729

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：N=C(NCCC[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1)N[N+](=O)[O-]

HCID178512174

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O.N=C(N)NCCC[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(=O)O

HCID178476721

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418390

未命名化合物

PROCEDURE

实验过程

100 mg of Z-Asn-Ser(Bzl)-D-Pro-Arg(NO2)-OBzl was reduced in the presence of palladium-carbon in the same manner as in Example 7-(4). The resulting product was purified by high-performance liquid chromatography at 12 ml/min. (flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase), subjected to Dowex 1×2 (acetate type) treatment and freeze-dried to obtain the desired compound.

WORKUP

后处理

customThe resulting product was purified by high-performance liquid chromatography at 12 ml/min. (flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase)
customfreeze-dried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4c4095edfe3944478a0b581251174ea5
来源数据集: uspto-grants-1994_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05349050
来源说明: uspto-grants-1994_09

反应 SMILES

[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:20]([N:22]1[CH2:50][CH2:49][CH2:48][C@@H:23]1[C:24]([NH:26][C@H:27]([C:38]([O:40]CC1C=CC=CC=1)=[O:39])[CH2:28][CH2:29][CH2:30][NH:31][C:32](=[NH:37])[NH:33][N+]([O-])=O)=[O:25])=[O:21])[CH2:11][O:12]CC1C=CC=CC=1)=[O:8])[CH2:3][C:4](=[O:6])[NH2:5]>[C].[Pd]>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:20]([N:22]1[CH2:50][CH2:49][CH2:48][C@@H:23]1[C:24]([NH:26][C@H:27]([C:38]([OH:40])=[O:39])[CH2:28][CH2:29][CH2:30][NH:31][C:32](=[NH:33])[NH2:37])=[O:25])=[O:21])[CH2:11][OH:12])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5].[CH3:27][C:38]([OH:40])=[O:39]