HRID2226730

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：N=C(NCCC[C@H](NC(=O)[C@@H]1CCCCN1C(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1)C(=O)OCc1ccccc1)N[N+](=O)[O-]

HCID178512170

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O.N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1)C(=O)O

HCID178476718

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418390

未命名化合物

PROCEDURE

实验过程

150 mg of Z-Pro-Asn-Ser(Bzl)-Pip-Arg(NO2)-OBzl was reduced in the presence of palladium-carbon in the same manner as in Example 12-(4). The resulting product was purified by high-performance liquid chromatography at 12 ml/min. (flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase), subjected to Dowex 1×2 (acetate type) treatment and freeze-dried to obtain the desired compound.

WORKUP

后处理

customThe resulting product was purified by high-performance liquid chromatography at 12 ml/min. (flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase)
customfreeze-dried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1c3a4fd44f874f1aa4637fc4ef71fa57
来源数据集: uspto-grants-1994_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05349050
来源说明: uspto-grants-1994_09

反应 SMILES

[N:1]1(C(OCC2C=CC=CC=2)=O)[CH2:58][CH2:57][CH2:56][C@H:2]1[C:3]([NH:5][C@H:6]([C:11]([NH:13][C@H:14]([C:24]([N:26]1[CH2:55][CH2:54][CH2:53][CH2:52][C@H:27]1[C:28]([NH:30][C@H:31]([C:42]([O:44]CC1C=CC=CC=1)=[O:43])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:41])[NH:37][N+]([O-])=O)=[O:29])=[O:25])[CH2:15][O:16]CC1C=CC=CC=1)=[O:12])[CH2:7][C:8](=[O:10])[NH2:9])=[O:4]>[C].[Pd]>[NH:1]1[CH2:58][CH2:57][CH2:56][C@H:2]1[C:3]([NH:5][C@H:6]([C:11]([NH:13][C@H:14]([C:24]([N:26]1[CH2:55][CH2:54][CH2:53][CH2:52][C@H:27]1[C:28]([NH:30][C@H:31]([C:42]([OH:44])=[O:43])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:37])[NH2:41])=[O:29])=[O:25])[CH2:15][OH:16])=[O:12])[CH2:7][C:8](=[O:10])[NH2:9])=[O:4].[CH3:31][C:42]([OH:44])=[O:43]