HCID 178512170, compound → HCID 178476718, compound

HRID 2226730Notes

Reaction equation

HRID 2226730 reaction equation
[N:1]1(C(OCC2C=CC=CC=2)=O)[CH2:58][CH2:57][CH2:56][C@H:2]1[C:3]([NH:5][C@H:6]([C:11]([NH:13][C@H:14]([C:24]([N:26]1[CH2:55][CH2:54][CH2:53][CH2:52][C@H:27]1[C:28]([NH:30][C@H:31]([C:42]([O:44]CC1C=CC=CC=1)=[O:43])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:41])[NH:37][N+]([O-])=O)=[O:29])=[O:25])[CH2:15][O:16]CC1C=CC=CC=1)=[O:12])[CH2:7][C:8](=[O:10])[NH2:9])=[O:4]>[C].[Pd]>[NH:1]1[CH2:58][CH2:57][CH2:56][C@H:2]1[C:3]([NH:5][C@H:6]([C:11]([NH:13][C@H:14]([C:24]([N:26]1[CH2:55][CH2:54][CH2:53][CH2:52][C@H:27]1[C:28]([NH:30][C@H:31]([C:42]([OH:44])=[O:43])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:37])[NH2:41])=[O:29])=[O:25])[CH2:15][OH:16])=[O:12])[CH2:7][C:8](=[O:10])[NH2:9])=[O:4].[CH3:31][C:42]([OH:44])=[O:43]

Participants

3

Reactant 1

HCID 178512170HCID 178512170, compound

Product 1

HCID 178476718HCID 178476718, compound

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

150 mg of Z-Pro-Asn-Ser(Bzl)-Pip-Arg(NO2)-OBzl was reduced in the presence of palladium-carbon in the same manner as in Example 12-(4). The resulting product was purified by high-performance liquid chromatography at 12 ml/min. (flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase), subjected to Dowex 1×2 (acetate type) treatment and freeze-dried to obtain the desired compound.

Workup

  1. customThe resulting product was purified by high-performance liquid chromatography at 12 ml/min. (flow rate), 0 to 10% (B) 20 min. linear gradient (A) (mobile phase)
  2. customfreeze-dried

Sources & evidence

ORD record
ord-1c3a4fd44f874f1aa4637fc4ef71fa57
Source dataset
uspto-grants-1994_09
Patent number
US05349050

Reaction notes

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