反应详情

The above ester (0.8 g, 1.8 mmol) was dissolved in ethanol (15 ml) and a 4 N sodium hydroxide solution (2 ml) was added. The mixture was stirred vigorously at room temperature for 4 h. The solvent was evaporated in vacuo to give an oily residue. Dichloromethane (100 ml) was added and the mixture was cooled on an ice-bath. A concentrated hydrochloric acid solution (1 ml) was added. The mixture was stirred vigorously for a few minutes and the phases were separated. The organic phase was dried over sodium sulphate and the solvent was evaporated in vacuo. The residue was re-evaporated with dichloromethane, dissolved in dichloromethane and left overnight at 4° C. The solid formed was isolated by filtration to give 0.6 g of the title compound as a solid.

1. customThe solvent was evaporated in vacuo
2. customto give an oily residue
3. temperaturethe mixture was cooled on an ice-bath
4. stirringThe mixture was stirred vigorously for a few minutes
5. customthe phases were separated
6. dry with materialThe organic phase was dried over sodium sulphate
7. customthe solvent was evaporated in vacuo
8. customThe residue was re-evaporated with dichloromethane
9. dissolutiondissolved in dichloromethane
10. waitleft overnight at 4° C
11. customThe solid formed
12. customwas isolated by filtration