HCID 24842608, compound → HCID 24842606, compound

HRID 2226744Notes

Reaction equation

HRID 2226744 reaction equation
[ClH:1].[CH:2]1[C:12]2[CH2:11][CH2:10][C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[C:7](=[CH:17][CH2:18][O:19][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][CH2:25][C@@H:24]([C:28]([OH:30])=[O:29])[CH2:23]3)[C:6]=2[CH:5]=[CH:4][CH:3]=1>CO.[Pd]>[ClH:1].[CH:2]1[C:12]2[CH2:11][CH2:10][C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[CH:7]([CH2:17][CH2:18][O:19][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][CH2:25][C@@H:24]([C:28]([OH:30])=[O:29])[CH2:23]3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 24842608HCID 24842608, compound

Product 1

HCID 24842606HCID 24842606, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The acid prepared in Example 3 (0.2 g, 0.5 mmol) was dissolved in methanol (10 ml) and stirred under an atmosphere of hydrogen for 16 h at room temperature in the presence of 10% palladium on carbon catalyst (50% aqueous paste). The mixture was filtered and the solvent was evaporated in vacuo to give an oily residue, which was re-evaporated from acetone and then crystallized from acetone (10 ml). This afforded 0.13 g (65%) of the title compound.

Workup

  1. filtrationThe mixture was filtered
  2. customthe solvent was evaporated in vacuo
  3. customto give an oily residue, which
  4. customwas re-evaporated from acetone
  5. customcrystallized from acetone (10 ml)

Sources & evidence

ORD record
ord-0607870fe34a425db7ec851ba73a9c6c
Source dataset
uspto-grants-1994_09
Patent number
US05348965

Reaction notes

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