Sodium Hydroxide → HCID 67768566, compound

Participants

Reaction Conditions

Reaction Steps

The above ester (1.0 g, 2.4 mmol) was dissolved in ethanol (25 ml) and a 2 N aqueous sodium hydroxide solution (4.7 ml) was added. The mixture was heated at 50° C. with stirring for 2.5 h. The volatiles were evaporated in vacuo and dichloromethane (100 ml) was added to the residue. The mixture was cooled on an ice-bath and a concentrated aqueous hydrochloric acid solution (1.2 ml) was added dropwise with vigorous stirring. The phases were separated and the organic phase was dried over magnesium sulphate. The solvent was evaporated in vacuo and the residue re-evaporated several times with acetone.

Provenance & Evidence