4-Fluorophenyl isocyanate → HCID 11743803, compound

HRID 222679Notes

Reaction equation

HRID 222679 reaction equation
[CH:1]1([N:5]2[CH2:11][CH2:10][C:9]3[CH:12]=[C:13]([O:16][CH:17]4[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]4)[CH:14]=[CH:15][C:8]=3[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[F:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]=[C:31]=[O:32])=[CH:26][CH:25]=1>>[F:23][C:24]1[CH:29]=[CH:28][C:27]([NH:30][C:31]([N:20]2[CH2:21][CH2:22][CH:17]([O:16][C:13]3[CH:14]=[CH:15][C:8]4[CH2:7][CH2:6][N:5]([CH:1]5[CH2:2][CH2:3][CH2:4]5)[CH2:11][CH2:10][C:9]=4[CH:12]=3)[CH2:18][CH2:19]2)=[O:32])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 709554-Fluorophenyl isocyanateHCID 685061053-cyclobutyl-7-(piperidin-4-yloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 11743803HCID 11743803, compound

Procedure

Example 67 was prepared from 3-cyclobutyl-7-(piperidin-4-yloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (E6) and 4-fluorophenyl-isocyanate using the method described for Example 66 (E66); MS (ES+) m/e 438 [M+H]+.

Sources & evidence

ORD record
ord-04de0ffddd2f4e568ed1b4dfb149e7bb
Source dataset
uspto-grants-2012_06
Patent number
US08207331B2

Reaction notes

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