Bromopinacolone → SBB058976

Participants

Reaction Steps

To a solution of 1-bromo-3,3-dimethylbutan-2-one (33.3 g, 0.19 mole) in dimethylsulfoxide (330 ml), sodium p-toluenesulfinate (34.9 g, 0.20 mole) was added in a small portion at 30°-40° C., and stirring was continued at 60°-70° C. for 18 hours. The resultant mixture was poured into ice-cold H2O (2 l), the precipitate was filtered by suction, washed with H2O and dried to give 41.6 g of 1-(p-toluenesulfonyl)-3,3-dimethylbutan-2-one as white crystals.

Provenance & Evidence