Hydrochloric Acid → Ethyl 3-ethoxy-3-iminopropionate hydrochloride

Participants

Reaction Steps

Hydrogen chloride gas was bubbled through a stirred solution of ethyl cyanoacetate (900 g, 7.96 moles), ethanol (410 ml, 7.0 moles) and diethyl ether (2.4 liters). The temperature was kept at <15° C. by use of a cooling bath. After 3.5 hours 395 g (10.8 moles) of HCl had been absorbed. The flask was kept in the cold room over the weekend. The crystalline white product was filtered off, washed with diethyl ether, then petroleum ether and dried under vacuum. The yield was 1210 g (88% ).

Provenance & Evidence