Formamide → Pyrido[3,2-d]pyrimidin-4-ol

HRID 2226834Notes

Reaction equation

HRID 2226834 reaction equation
[NH2:1][C:2]1[C:3]([C:8]([OH:10])=O)=[N:4][CH:5]=[CH:6][CH:7]=1.[CH:11]([NH2:13])=O>O>[N:1]1[C:2]2[CH:7]=[CH:6][CH:5]=[N:4][C:3]=2[C:8](=[O:10])[NH:13][CH:11]=1

Participants

4

Reactant 2

HCID 713FormamideHCID 738363-Aminopicolinic acid

Product 1

HCID 135703334Pyrido[3,2-d]pyrimidin-4-ol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 6.5 g of 3-amino-pyridine-2-carboxylic acid in 9 g of formamide was heated in an oil bath while stirring. The temperature was increased from 130° C. to 180° C. over a two hour period, then the mixture was allowed to cool. The mixture was then diluted with water. The solids were collected and washed with fresh water, then dried. Yield 4.6 g. M.P. 346°-347° C.

Workup

  1. temperaturewas heated in an oil bath
  2. temperatureThe temperature was increased from 130° C. to 180° C. over a two hour period
  3. temperatureto cool
  4. customThe solids were collected
  5. washwashed with fresh water
  6. customdried

Sources & evidence

ORD record
ord-78706222c6cf4bbf89b94d694b175bc9
Source dataset
uspto-grants-1994_09
Patent number
US05350749

Reaction notes

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