Trimethylsilyl iodide → HCID 14966680, compound

Participants

Reaction Conditions

Reaction Steps

7.7 g of 4-oxopiperidinomethylene bisphosphonic acid ethyl ester and 12 ml of trimethylsilyl iodide (specific gravity: 1.41) were stirred at 0° C. for 30 minutes in 120 ml of CCl4. Then, the reaction solution was distilled under reduced pressure. To the residue, 50 ml of water and 200 ml of CH3OH were added, and the mixture was stirred at a temperature of from 25 to 30° C. for 5 hours. The reaction solution was distilled, and the residue was purified by silica gel column chromatography (chloroform/methanol=9/1) to give 2.0 g (yield: 37%) 4-oxopiperidinomethylene bisphosphonic acid.

Provenance & Evidence