HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2226848Generated: October 31, 2026
Water → 3,9-Dihydro-9-phenyl-furo[2,3-b][1,8]-naphthyridin-4(2H)-one
https://huagongshe.com/reaction/2226848
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Phosphorus oxide (P4O10) | HCID 14812 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-hydroxy-3-(2-hydroxyethyl)-1-phenyl-1,8-naphthyridin-2(1H)-one | HCID 54723667 | — |
| Solvent | Methanesulfonic Acid | HCID 6395 | — |
| Product | 3,9-Dihydro-9-phenyl-furo[2,3-b][1,8]-naphthyridin-4(2H)-one | HCID 13823468 | — |
Reaction Steps
A solution of 4-hydroxy-3-(2-hydroxyethyl)-1-phenyl-1,8-naphthyridin-2 (1H) -one in Eaton's Reage P2O5 in methane sulfonic acid; 40 ml.) was stirred in an atmosphere of nitrogen and was heated to 70° C. for 2 hr. After cooling, the product was poured into water, adjusted to pH 4 with NaHCO3, filtered, washed with water, air dried and recrystallized from isopropanol with decolorization to yield the product, m.p. 245°-247° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05350755 |
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| Source dataset | uspto-grants-1994_09 |
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| ORD ID | ord-7b7fe2d18a7f4542bfc8b383efa0148a |
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| Source note | uspto-grants-1994_09 |
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