HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 3-Chloro-5-methoxybenzo[b]thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 3-Chloro-5-methoxybenzo[b]thiophene-2-carbonyl chloride | HCID 10199109 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Chloro-5-methoxybenzo[b]thiophene-2-carboxamide | HCID 10681595 | — |
Reaction Steps
To a suspension of 3-chloro-5-methoxybenzo[b]thiophene-2-carbonyl chloride (1.52 g, 5.82 mmol) [Connor D. T., et al., J. Med. Chem. 35, 935 (1992)] in 80 mL of toluene at 50° C. is added dropwise 10 mL of aqueous NH4OH. The resulting precipitate is collected by filtration and recrystallized from methanol to provide 3-chloro-5-methoxybenzo[b]thiophene2-carboxamide; mp=220°-222° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05350748 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-abee970752414950a23fc988f3a26d63 |
| Source note | uspto-grants-1994_09 |