Ammonium Hydroxide → HCID 15233883, compound

Participants

Reaction Steps

A mixture of 4-chloro-3-[(1-methylethyl)thio]benzo[b]thiophene-2-carboxylic acid (0.43 g, 1.5 mmol) and 1,1'-carbonyldiimidazole (0.25 g, 1.5 mmol) in 5.0 mL of acetonitrile is stirred at reflux for 2 hours. The cooled reaction solution is added slowly to 20 mL of cold ammonium hydroxide solution. The precipitated solid is filtered, washed with water, and recrystallized from aqueous acetonitrile to give 0.15 g (35%) of product; mp=182°-184° C.

Provenance & Evidence