HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → HCID 10852993, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 5-(Benzyloxy)-3-chloro-1-benzothiophene-2-carbonyl chloride | HCID 14673582 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 10852993 | HCID 10852993 | 84% |
Reaction Steps
To a warm solution of 3-chloro-5-(phenylmethoxy)benzo[b]thiophene-2-carbonyl chloride (2.0 g, 6 mmol) [Connor D. T., et al., J. Med. Chem, 35, 935, (1992)] in 20 mL of toluene is added dropwise 10 mL of aqueous NH4OH. The resulting precipitate is collected by filtration washing with ethyl alcohol to provide 3-chloro-5-(phenylmethoxy)benzo[b]thiophene-2-carboxamide in 84% yield; mp=205.5°-206° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05350748 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-1d5d497b3c4247d9a2f84e31ba5787dd |
| Source note | uspto-grants-1994_09 |