HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → Methyl 3-(dimethylamino)-4-methoxybenzo[b]thiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Methyl 3-amino-4-methoxy-1-benzothiophene-2-carboxylate | HCID 10799875 | — |
| Reactant | Methyl 4-chloro-3-(dimethylamino)benzo[b]thiophene-2-carboxylate | HCID 18963790 | — |
| Product | Methyl 3-(dimethylamino)-4-methoxybenzo[b]thiophene-2-carboxylate | HCID 18963783 | — |
Reaction Steps
Alkylation of methyl 3-amino-4-methoxybenzo[b]thiophene-2-carboxylate (1.4 g, 5.9 mmol) [Beck J. R., supra] with paraformaldehyde as described for the preparation of methyl 4-chloro-3-(dimethylamino)benzo[b]thiophene-2-carboxylate provides methyl 3-(dimethylamino)-4-methoxybenzo[b]thiophene-2-carboxylate as a crude solid suitable for further synthesis; mp=69°-73° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05350748 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-78336d3907a5400098c6bbf2ec209efd |
| Source note | uspto-grants-1994_09 |