HCID 19387898, compound → HCID 19387908, compound

HRID 2226890Notes

Reaction equation

HRID 2226890 reaction equation
Br.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]#[C:9][CH2:10]Br.[F:12][C:13]1[CH:14]=[C:15]([OH:28])[CH:16]=[C:17]([C:19]2([O:26][CH3:27])[CH2:23][CH2:22][CH2:21][CH:20]2[O:24][CH3:25])[CH:18]=1>>[F:12][C:13]1[CH:14]=[C:15]([O:28][CH2:10][C:9]#[C:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][N:2]=2)[CH:16]=[C:17]([C:19]2([O:26][CH3:27])[CH2:23][CH2:22][CH2:21][CH:20]2[O:24][CH3:25])[CH:18]=1

Participants

3

Reactant 2

HCID 19387898HCID 19387898, compoundHCID 67780678HCID 67780678, compound

Product 1

HCID 19387908HCID 19387908, compoundYield 83%

Procedure

Using the procedure described in Example 1, 3-(2-pyridyl)prop-2-yn-1-yl bromide hydrobromide was reacted with (1RS,2SR)-1-(5-fluoro-3-hydroxyphenyl)-1,2-dimethoxycyclopentane to give (1RS,2SR)-1-[5-fluoro-3-(3-(2-pyridyl)prop-2-yn-1-yloxy)phenyl]-1,2-dimethoxycyclopentane in 83% yield, as an oil.

Sources & evidence

ORD record
ord-021015ec42774c4ea71d0166608bd8ca
Source dataset
uspto-grants-1994_09
Patent number
US05350754

Reaction notes

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