Potassium Hydroxide → HCID 178418251, compound

Participants

Reaction Steps

305 ml of a 1M solution of (NH4)2Ce(NO3)6 in H2O are added slowly at 10°-15° C. to 20 g (0.106 mol) of 2-butyl-4-chloro-5-hydroxymethylimidazole in 350 ml of glacial acetic acid. After 2.5 h at RT, the pH is adjusted to 4 with 2N KOH (20° C. during addition of the base). After extraction 4× with 500 ml of CH2Cl2 each time the combined organic extracts are washed 3× with 300 ml of saturated aqueous NaHCO3 solution each time, dried with Na2SO4 and concentrated, resulting in the title compound as a colorless solid (18 g). Melting point was 90° C.

Provenance & Evidence